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COOH-PEG12-COOtBu

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Category	COOH-PEGn-COOtBu
Catalog NO.	BPG-1561
Product Name	COOH-PEG12-COOtBu
Molecular Formula	C32H62O16
Molecular Weight	702.83

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Product Information

Description	COOH-PEG12-COOtBu is a PEG linker containing a t-butyl-protected carboxyl group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The t-butyl-protected carboxyl group can be deprotected under acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media.
Synonyms	Acid-PEG12-t-butyl ester; Acid-PEG12-C2-Boc; HOOCCH2CH2O-PEG11-CH2CH2COOtBu; COOH-PEG12-OtBu; 2,2-Dimethyl-4-oxo-3,7,10,13,16,19,22,25,28,31,34,37,40-tridecaoxatritetracontan-43-oic acid; 4,7,10,13,16,19,22,25,28,31,34,37-Dodecaoxatetracontane-1,40-dioic acid, mono(1,1-dimethylethyl) ester
IUPAC Name	3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES	CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O
InChI	InChI=1S/C32H62O16/c1-32(2,3)48-31(35)5-7-37-9-11-39-13-15-41-17-19-43-21-23-45-25-27-47-29-28-46-26-24-44-22-20-42-18-16-40-14-12-38-10-8-36-6-4-30(33)34/h4-29H2,1-3H3,(H,33,34)
InChIKey	IZMSFHWKXCFBAM-UHFFFAOYSA-N
Boiling Point	706.0±60.0°C at 760 mmHg
Purity	≥95%
Density	1.1±0.1 g/cm3
Appearance	White Solid
Storage	Store at 2-8°C

COOH-PEG12-COOtBu, a versatile PEG derivative with distinctive characteristics, finds widespread utility in the biomedical and biotechnological realms. Here are four key applications of COOH-PEG12-COOtBu, presented with high perplexity and burstiness:

Drug Delivery Systems: Embracing the potential of COOH-PEG12-COOtBu elevates the solubility, stability, and bioavailability of therapeutic agents to unprecedented heights. Conjoining drugs with this PEG derivative optimizes the pharmacokinetics and therapeutic index of these compounds, culminating in a paradigm shift towards more efficient drug delivery with attenuated side effects.

Bioconjugation: Serving as an impeccable linker, COOH-PEG12-COOtBu expedites the attachment of biomolecules, such as proteins, antibodies, and peptides, to diverse surfaces or molecules. The supple PEG backbone diminishes steric hindrance while the terminal carboxylic acid and tert-butyl ester groups streamline conjugation processes. This application assumes a pivotal role in propelling advancements in sensors, diagnostics, and targeted therapeutic modalities.

Surface Functionalization: In the domain of surface modification, COOH-PEG12-COOtBu emerges as an indispensable powerhouse for transforming the surfaces of nanoparticles, implants, and medical devices. Enrobing these surfaces with this compound thwarts protein adsorption, diminishes immunogenic responses, enhances biocompatibility, and prolongs the functionality of medical devices.

Controlled Release Formulations: By harnessing the innate properties of COOH-PEG12-COOtBu, controlled release systems for drugs and bioactive molecules are meticulously crafted. This derivative engenders the development of hydrogels, micelles, and nanoparticles adept at encapsulating payloads and dispensing them in a regulated manner over time. Such formulations prove exceedingly advantageous for dispensing drugs mandating precise dosing and sustained release.

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