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COOH-PEG11-COOtBu

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Category	COOH-PEGn-COOtBu
Catalog NO.	BPG-1559
Product Name	COOH-PEG11-COOtBu
Molecular Formula	C30H58O15
Molecular Weight	658.78

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Product Information

Description	COOH-PEG11-COOtBu is a PEG linker containing a t-butyl-protected carboxyl group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The t-butyl-protected carboxyl group can be deprotected under acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media.
Synonyms	Acid-PEG11-t-butyl ester; Acid-PEG11-C2-Boc; HOOCCH2CH2O-PEG10-CH2CH2COOtBu; COOH-PEG11-OtBu; 2,2-Dimethyl-4-oxo-3,7,10,13,16,19,22,25,28,31,34,37-dodecaoxatetracontan-40-oic acid
IUPAC Name	3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES	CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O
InChI	InChI=1S/C30H58O15/c1-30(2,3)45-29(33)5-7-35-9-11-37-13-15-39-17-19-41-21-23-43-25-27-44-26-24-42-22-20-40-18-16-38-14-12-36-10-8-34-6-4-28(31)32/h4-27H2,1-3H3,(H,31,32)
InChIKey	IGTATCTUNWMNEP-UHFFFAOYSA-N
Purity	≥95%
Appearance	Pale Yellow or Colorless Oily Matter
Storage	Store at 2-8°C

COOH-PEG11-COOtBu, also known as a carboxyl-functionalized polyethylene glycol (PEG) derivative, is a versatile compound widely utilized in diverse biochemical and pharmaceutical applications. Here, we explore its key applications with a high degree of perplexity and burstiness:

Drug Delivery Systems: Embracing the realm of drug delivery systems, COOH-PEG11-COOtBu emerges as a pivotal player owing to its exceptional biocompatibility and proficiency in enhancing drug solubility. The presence of carboxyl groups facilitates the covalent attachment of therapeutic agents, paving the way for the creation of prodrugs or targeted delivery platforms. This strategic maneuver not only augments the pharmacokinetics and bioavailability of drugs but also opens new frontiers in precision medicine.

Surface Modification: Within biomedical engineering, COOH-PEG11-COOtBu assumes a crucial role in the realm of surface modification for medical devices and biomaterials. By grafting this compound onto surfaces, a hydrophilic barrier is erected, mitigating immune responses and reducing non-specific protein adsorption. Such applications are instrumental in fostering the development of enduring implants and diagnostic devices with enhanced biocompatibility.

Protein Conjugation: Delving into the domain of protein conjugation, COOH-PEG11-COOtBu emerges as a transformative agent, elevating the stability, solubility, and circulating half-life of proteins and peptides. The intricate process of PEGylation entails the attachment of PEG chains to biologics, effectively curbing immunogenicity and proteolytic degradation. This refinement serves as a cornerstone for producing therapeutic proteins that are not only more efficacious but also better tolerated by the human body.

Diagnostic Imaging: As we venture into the realm of diagnostic imaging, COOH-PEG11-COOtBu unveils its potential as a game-changer capable of enhancing the solubility and circulation time of imaging agents. By conjugating with PEGylated imaging probes, the clarity and specificity of diagnostic techniques such as magnetic resonance imaging (MRI) and positron emission tomography (PET) are significantly amplified. This advancement translates into heightened accuracy and utility in clinical diagnostic settings, revolutionizing the landscape of medical imaging technology.

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