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Br-PEG9-acid

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Category Br-PEGn-acid
Catalog NO. BPG-1369
Product Name Br-PEG9-acid
Molecular Formula C21H41BrO11
Molecular Weight 549.45
Br-PEG9-acid
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Product Information

Description Br-PEG9-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Synonyms Bromo-PEG9-propionic acid; Br-PEG9-CH2CH2COOH; Bromo-PEG9-Acid; 1-bromo-3,6,9,12,15,18,21,24,27-nonaoxatriacontan-30-oic acid
IUPAC Name 3-[2-[2-[2-[2-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES O=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCBr
InChI InChI=1S/C21H41BrO11/c22-2-4-26-6-8-28-10-12-30-14-16-32-18-20-33-19-17-31-15-13-29-11-9-27-7-5-25-3-1-21(23)24/h1-20H2,(H,23,24)
InChIKey LUQQHRBZEHRXTL-UHFFFAOYSA-N
Purity ≥95%
Appearance Pale Yellow or Colorless Oily Matter
Storage Store at 2-8°C

Br-PEG9-acid is a polyethylene glycol-based compound frequently used in various biotechnological and chemical applications. Here are some key applications of Br-PEG9-acid:

Drug Delivery Systems: Br-PEG9-acid is commonly used to enhance the solubility and stability of drug molecules. By conjugating drugs with Br-PEG9-acid, researchers can improve the pharmacokinetics and biodistribution of therapeutic agents. This approach increases the efficiency and efficacy of drug delivery, often reducing the dosage frequency required.

Bioconjugation: In the field of bioconjugation, Br-PEG9-acid serves as a linker to attach biomolecules like peptides or proteins to synthetic materials or other biomolecules. This allows for the creation of hybrid molecules with novel properties and functionalities. It is particularly useful in creating targeted drug therapies and diagnostic tools.

Surface Modification: Br-PEG9-acid is utilized for surface modification of nanoparticles and biomaterials to improve their biocompatibility and functionality. By coating surfaces with Br-PEG9-acid, researchers can reduce non-specific binding and enhance specific interactions. This application is critical in the development of biosensors, implantable devices, and other biomedical applications.

Chemical Synthesis: In chemical synthesis, Br-PEG9-acid is used as a versatile reagent to introduce polyethylene glycol (PEG) chains into various organic compounds. This modification is often necessary to improve the solubility and handling of hydrophobic molecules. The resulting PEGylated compounds have diverse applications in pharmaceuticals, biotechnology, and materials science.

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