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Br-PEG12-THP

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Category Br-PEGn-THP
Catalog NO. BPG-1404
Product Name Br-PEG12-THP
Molecular Formula C29H57BrO13
Molecular Weight 693.67
Br-PEG12-THP
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Product Information

Description Br-PEG12-THP is a polyethylene glycol (PEG)-based PROTAC linker that can be used in the synthesis of a series of PROTACs.
Synonyms Bromo-PEG12-THP; THP-PEG12-bromide; 2-((35-bromo-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl)oxy)tetrahydro-2H-pyran
IUPAC Name 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]oxane
Canonical SMILES BrCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC1OCCCC1
InChI InChI=1S/C29H57BrO13/c30-4-6-31-7-8-32-9-10-33-11-12-34-13-14-35-15-16-36-17-18-37-19-20-38-21-22-39-23-24-40-25-26-41-27-28-43-29-3-1-2-5-42-29/h29H,1-28H2
InChIKey RFIOSSNLBXXZQB-UHFFFAOYSA-N
Purity ≥95%
Storage Store at 2-8°C

Br-PEG12-THP, a versatile reagent, finds applications in diverse biochemical and pharmaceutical domains. Here are four key applications of Br-PEG12-THP:

Drug Delivery Systems: Driving innovation in drug delivery, Br-PEG12-THP plays a pivotal role in enhancing the solubility, stability, and bioavailability of therapeutic agents. By forming conjugates with drugs, it elevates their pharmacokinetic profiles and facilitates precise delivery to targeted tissues or cells, minimizing adverse effects and augmenting therapeutic effectiveness.

Bioconjugation: Widely utilized in bioconjugation procedures, Br-PEG12-THP acts as a crucial linker for attaching biomolecules, such as antibodies, peptides, or proteins, to diverse surfaces or molecules. This process enables the creation of multifunctional complexes for applications in diagnostics, therapeutics, or bioanalytical realms. The PEGylation process not only enhances the biocompatibility but also mitigates the immunogenicity of the conjugated biomolecules.

Surface Modification: In the realm of surface modification, Br-PEG12-THP emerges as a key player in enhancing biocompatibility and reducing nonspecific binding. By coating medical devices, biosensors, or other surfaces with Br-PEG12-THP, it effectively reduces protein adsorption and cell adhesion. This property proves invaluable in the development of biomedical devices and implants, mitigating risks of infection and immune responses.

Pharmaceutical Research: In the landscape of pharmaceutical research, Br-PEG12-THP finds extensive utility in synthesizing novel therapeutic compounds and studying drug interactions. Its capacity to form stable, water-soluble conjugates with diverse molecules positions it as a valuable asset in drug formulation and testing.

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PEGylation of Peptides and Proteins

PEGylation of Peptides
and Proteins

Reduce the Immunogenicity of Peptide/Protein Drugs

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