Bis-PEG2-t-butyl ester
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Category | COOtBu-PEGn-COOtBu |
Catalog NO. | BPG-1573 |
Product Name | Bis-PEG2-t-butyl ester |
CAS | 1611468-28-0 |
Molecular Formula | C16H30O6 |
Molecular Weight | 318.41 |
- Scheme Design
- Custom Synthesis
- cGMP Manufacturing
- Quality Assurance
- Product Information
- Application
- References
- Documents
- Reviews
Description | Bis-PEG2-t-butyl ester is a polyethylene glycol (PEG)-based PROTAC linker that can be used in the synthesis of a series of PROTACs. |
Synonyms | Bis(2-methyl-2-propanyl) 3,3'-[1,2-ethanediylbis(oxy)]dipropanoate; Propanoic acid, 3,3'-[1,2-ethanediylbis(oxy)]bis-, 1,1'-bis(1,1-dimethylethyl) ester; Bis-PEG2-Boc; tert-butyl 3-{2-[3-(tert-butoxy)-3-oxopropoxy]ethoxy}propanoate |
IUPAC Name | tert-butyl 3-[2-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]ethoxy]propanoate |
Canonical SMILES | CC(C)(C)OC(=O)CCOCCOCCC(=O)OC(C)(C)C |
InChI | InChI=1S/C16H30O6/c1-15(2,3)21-13(17)7-9-19-11-12-20-10-8-14(18)22-16(4,5)6/h7-12H2,1-6H3 |
InChIKey | ALKAASHAFVQEJO-UHFFFAOYSA-N |
Boiling Point | 374.1±22.0°C (Predicted) |
Purity | ≥95% |
Density | 1.019±0.06 g/cm3 (Predicted) |
Appearance | Pale Yellow or Colorless Oily Matter |
Storage | Store at 2-8°C |
Bis-PEG2-t-butyl ester, a versatile chemical compound renowned for its myriad functionalities in diverse biomedical applications, serves as a cornerstone in various cutting-edge domains. Here are four key applications: Drug Delivery Systems: Positioned at the forefront of advanced drug delivery systems, Bis-PEG2-t-butyl ester emerges as a pivotal component orchestrating precise drug localization and enhancing treatment efficacy. By acting as a crucial linker molecule, this compound facilitates the coupling of therapeutic agents to carrier molecules like nanoparticles or liposomes, heralding a new era of targeted drug delivery with unparalleled precision and minimal adverse effects. Protein PEGylation: Within the intricate realm of protein PEGylation, Bis-PEG2-t-butyl ester shines brightly, propelling the solubility and stability of protein-based drugs to unprecedented heights. This compound acts as a linchpin in the conjugation of polyethylene glycol (PEG) chains to proteins or peptides, prolonging their circulation in the bloodstream and optimizing pharmacokinetic properties. Such enhancements are integral in maximizing the efficacy of biologic drugs, ultimately leading to improved patient outcomes in clinical settings. Bioconjugation: Embracing the complexities of bioconjugation techniques, Bis-PEG2-t-butyl ester assumes a significant role in the fusion of biomolecules, elevating the sensitivity and specificity of diagnostic assays and imaging studies. By linking antibodies to enzymes or fluorescent markers, this compound facilitates enhanced detection capabilities and diagnostic accuracies in diverse biotechnological and biomedical applications. Surface Modification: Extending beyond its inherent functions, Bis-PEG2-t-butyl ester finds new avenues in the realm of surface modification for medical devices and biomaterials. By mitigating protein adsorption and cellular adhesion, this compound reduces the risk of biofouling, thereby enhancing biocompatibility and ensuring optimal performance and safety in clinical environments. |
Reviews
If you have any suggestions or comments about mPEG-Br, please submit a review immediately.
Why BOC Sciences?
-
Large Stock
More than 2000+ products in inventory
-
Global Delivery
Warehouses in multiple cities to ensure fast delivery
-
mg to kg
Multi specification for academic research and industrial production
-
24/7 Technical Support
Strict process parameter control to ensure product quality
Products
- Lipids
- PEG Derivatives by Structure
-
PEG Derivatives by Functional Group
- Acrylate/Acrylamide/Methacrylate PEG
- Aldehyde (Ald/CHO)PEG
- Alkyne PEG
- Amino PEG, PEG amine(-NH2)
- Azide PEG, Azido PEG(-N3)
- Biotin PEG
- Boc/Fmoc protected amine PEG
- Carboxylic Acid(-COOH) PEG
- Cholesterol PEG
- DBCO PEG
- DNP PEG
- DSPE PEG
- Epoxide glycidyl ether PEG
- FITC PEG
- Folate PEG
- Halide (chloride, bromide) PEG
- Hydrazide PEG
- Hydroxyl(-OH) PEG
- Maleimide(-MAL) PEG
- NHS ester PEG
- Nitrophenyl carbonate (NPC) PEG
- Norbornene PEG
- Olefin/Alkene/Vinyl PEG
- Orthopyridyl disulfide (OPSS) PEG
- Phosphate PEG
- Rhodamine PEG
- SCM PEG
- Silane PEG
- SPDP PEG
- Sulfonate (tosyl, mesyl, tresyl) PEG
- tert-Butyl protected carboxylate PEG
- Thiol(-SH) PEG
- Vinylsulfone PEG
- PEG Copolymers
-
PEG Raw Materials
- Small-molecule Polyethylene Glycol
- Polyethylene Glycol 1000
- Polyethylene Glycol 10000
- Polyethylene Glycol 1500
- Polyethylene Glycol 200
- Polyethylene Glycol 2000
- Polyethylene Glycol 20000
- Polyethylene Glycol 400
- Polyethylene Glycol 4000
- Polyethylene Glycol 600
- Polyethylene Glycol 6000
- Polyethylene Glycol 800
- Polyethylene Glycol 8000
Resources
-
Technical Information
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- How to Perform Polyethylene Glycol (PEG) Modification?
- Hydrophobic Interaction Chromatography (HIC) Technique
- Introduction of Polyethylene Glycol (PEG)
- Ion Exchange Chromatography (IEX) Technique
- PEG for Chemical Synthesis
- PEG for Cosmetic Application
- PEG for Drug Delivery
- PEG for Imaging Diagnosis
- PEG for Pharmaceutical Preparation
- PEG for Tissue Engineering
- PEG Purification Techniques of Plasmid DNA
- PEGylated Protein Purification Techniques
- Polyethylene Glycol (PEG) Modifier Selection Guide
- Radiolabeling Technique
- SDS-PAGE Technique
- Size Exclusion Chromatography (SEC) Technique
- Ultrafiltration Technique
-
Industry News
- Applications of PEG-DSPE: Drug Carriers and Drug Delivery
- Applications of Polyethylene Glycol (PEG) as Medical Devices
- Cholesterol: Definition, Structure, Synthesis, Types and Functions
- Classification of Lipid-Based Vaccine Adjuvants
- FDA approved PEGylated Products
- FDA-Approved Antibody-Drug Conjugates up to 2024
- How are Liposomes Different from Micelles?
- How Lipid Nanoparticles (LNPs) Deliver RNA Drugs?
- Hyaluronic Acid & PEGylated Hyaluronic Acid
- Ionizable Lipids for RNA Delivery
- Lipid Classification and Drug Delivery Systems
- Lipid Formulations: Key Absorption-Enhancing Technologies in New Drug Development
- Lipid-Drug Conjugates (LDCs) for Nanoparticle Drug Delivery
- Liposome in Drug Delivery
- Overview of Liposome Preparation Process
- PEG in Pharmaceutical Preparations (I): Solvents, Lubricants, Adhesives and More
- PEG in Pharmaceutical Preparations (II): Stabilizers, Plasticizers and Modification Materials
- PEG Linkers in Antibody Drug Conjugates and PROTACs
- PEG-DSPE Block Copolymers and Their Derivatives
- PEGylated Drugs: Definition, Structure, Classification and Benefits
- PEGylated RGD Peptides: A Promising Tool for Targeted Drug Delivery
- Pharmacokinetics and Bioanalysis of PEGylated Drugs
- Polyethylene Glycol (PEG) Modified Targeting Nanomaterials
- Preparation Method of PEG Hydrogel
- The PROTAC Technology in Drug Development
- Vaccines: Definition, History, Ingredients, Types and Mechanism of Action
- What are Lipid Excipients and Their Applications?
- What are Lipid Nanoparticles and Their Applications?
- What are Lipid-Drug Conjugates (LDCs)?
- What are Lipids?
- What are Monodispersed and Polydispersed PEGs?
- What are PEG Lipids?
- What are Phospholipids?
- What are Sterols? - Definition, Structure, Function, Examples and Uses
- What is Biotinylation and Biotinylated PEG?
- What is Click Chemistry?
- What is Hydrogel?
- What is Methoxy Polyethylene Glycol (mPEG)?
- What is Nanogels and Its Applications?
- What is the Formulation of Lipid Nanoparticles (LNPs)?
Our Feature
BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.
PEGylation of Peptides
and Proteins
Reduce the Immunogenicity of Peptide/Protein Drugs
Learn More
APPLICATIONS
PEG linkers For Drug
Improved Circulation Half-Life
Learn More
Have Customer Reviewed On Us?
Chat With Us