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Biotin-PEG3-propionic acid

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Category Biotin PEG
Catalog NO. BPG-2178
Product Name Biotin-PEG3-propionic acid
CAS 252881-76-8
Molecular Formula C19H33N3O7S
Molecular Weight 447.55
Biotin-PEG3-propionic acid
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Description (+)-Biotin-PEG3-acid (CAS# 252881-76-8) is a useful research chemical.
Synonyms 3-[2-[2-[2-[[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethoxy]ethoxy]ethoxy]propanoic acid; 3-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethoxy]propanoic acid
IUPAC Name 3-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES C1C2C(C(S1)CCCCC(=O)NCCOCCOCCOCCC(=O)O)NC(=O)N2
InChI InChI=1S/C19H33N3O7S/c23-16(4-2-1-3-15-18-14(13-30-15)21-19(26)22-18)20-6-8-28-10-12-29-11-9-27-7-5-17(24)25/h14-15,18H,1-13H2,(H,20,23)(H,24,25)(H2,21,22,26)/t14-,15-,18-/m0/s1
InChIKey HRGPPBXEZFBGDJ-MPGHIAIKSA-N
Boiling Point 770.7±60.0 °C at 760 mmHg
Purity >97%
Density 1.2±0.1 g/cm3
Solubility In DMSO: 100 mg/mL (223.44 mM; Need ultrasonic)
Appearance White Powder
Storage 4°C, sealed storage, away from moisture; In solvent, -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Exact Mass 447.20392157
LogP 0.87820

Biotin-PEG3-propionic acid, a versatile bifunctional molecule with diverse applications, finds widespread use in biochemical and biotechnological fields. Here are four key applications of Biotin-PEG3-propionic acid, presented with a high degree of perplexity and burstiness:

Bioconjugation: Serving as a crucial link in bioconjugation processes, Biotin-PEG3-propionic acid facilitates connections between biomolecules, such as proteins, peptides, and nucleic acids, with various surfaces. The biotin component plays a pivotal role in establishing robust and specific bonds with streptavidin or avidin, making it an exceptional choice for targeted assays and detection systems. This method of conjugation not only enhances the stability and functionality of biomolecules but also ensures their effectiveness across a myriad of experimental scenarios, pushing the boundaries of bioconjugation technologies.

Drug Delivery Systems: Positioned at the forefront of drug delivery innovations, Biotin-PEG3-propionic acid opens new avenues for creating precise and targeted drug delivery vehicles. By linking therapeutic agents to the biotinylated PEG linker, drugs can be directed to specific cells or tissues through biotin-streptavidin interactions. This personalized delivery strategy enhances drug efficacy while minimizing systemic toxicity, marking a significant advancement in therapeutic interventions and reshaping the landscape of drug delivery systems.

Diagnostic Imaging: Playing a pivotal role in the advancement of diagnostic imaging technologies, Biotin-PEG3-propionic acid contributes to the development of imaging probes for diagnostic purposes. When combined with imaging agents like fluorophores or nanoparticles, it enables accurate localization and visualization of biological structures both in vivo and in vitro. This application is indispensable for disease diagnosis, monitoring disease progression, and evaluating treatment effectiveness, revolutionizing the realm of medical imaging with its cutting-edge capabilities.

Immobilization of Biomolecules: In the realm of biosensors and analytical devices, Biotin-PEG3-propionic acid emerges as a critical element in the immobilization of biomolecules on diverse surfaces. The flexible PEG linker mitigates nonspecific binding, ensuring that the immobilized molecules retain their activity and accessibility. This technique plays a pivotal role in crafting highly sensitive and specific biosensing platforms, driving innovation in biotechnological applications, and propelling the development of advanced analytical devices.

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PEGylation of Peptides and Proteins

PEGylation of Peptides
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