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Benzyl-PEG5-alcohol

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Category	Small-molecule Heterobifunctional PEG
Catalog NO.	BPG-1970
Product Name	Benzyl-PEG5-alcohol
CAS	57671-28-0
Molecular Formula	C17H28O6
Molecular Weight	328.40

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Description	BnO-PEG5-OH is a polyethylene glycol (PEG)-based PROTAC linker. BnO-PEG5-OH can be used in the synthesis of a series of PROTACs.
Synonyms	Pentaethylene glycol monobenzyl ether; 1-Phenyl-2,5,8,11,14-pentaoxahexadecan-16-ol; BnO-PEG5-OH; 2-[2-[2-[2-[2-(Benzyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol; BzO-dPEG5-OH; Bn-PEG5-OH
IUPAC Name	2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol
Canonical SMILES	C1=CC=C(C=C1)COCCOCCOCCOCCOCCO
InChI	InChI=1S/C17H28O6/c18-6-7-19-8-9-20-10-11-21-12-13-22-14-15-23-16-17-4-2-1-3-5-17/h1-5,18H,6-16H2
InChIKey	UMUSOTNGYAALST-UHFFFAOYSA-N
Boiling Point	437.2±40.0 °C at 760 mmHg
Purity	≥95%
Density	1.1±0.1 g/cm3
Solubility	Soluble in DCM, DMF, DMSO
Related CAS	26403-74-7 (polymer) 1201808-31-2 (polymer)
Appearance	Pale Yellow or Colorless Oily Matter
Storage	Store at 2-8°C

Benzyl-PEG5-alcohol, a versatile compound widely utilized in various bioscience and pharmaceutical settings, boasts an array of applications with high perplexity and burstiness.

Drug Delivery Systems: Incorporating Benzyl-PEG5-alcohol into drug delivery systems elevates the solubility and bioavailability of therapeutic agents. The PEG component, known for reducing immunogenicity and prolonging circulation time in the bloodstream, emerges as a pivotal factor in enhancing drug efficacy and curbing side effects.

Protein Modification: Leveraging Benzyl-PEG5-alcohol for protein pegylation entails attaching PEG chains to protein molecules, augmenting their stability and solubility for enhanced therapeutic potential. This modification not only boosts the effectiveness of therapeutic proteins in disease treatment but also mitigates immunogenicity, potentially diminishing adverse immune responses.

Nanoparticle Synthesis: In the domain of nanotechnology, Benzyl-PEG5-alcohol finds application in nanoparticle functionalization through PEG chain attachment. This process enhances the biocompatibility and circulation duration of nanoparticles in biological systems, pivotal for the development of nanoparticle systems geared towards targeted drug or imaging agent delivery.

Surface Coatings: Employing Benzyl-PEG5-alcohol in creating antifouling surface coatings for medical devices and implants proves instrumental in averting protein, cell, and microorganism adherence to surfaces, thereby minimizing infection risks and bolstering device performance. This application holds particular significance in enhancing the efficacy of catheters, stents, and other implantable devices.

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