Benzyl-PEG11-Boc
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Category | Benzyl-PEGn-Boc |
Catalog NO. | BPG-0108 |
Product Name | Benzyl-PEG11-Boc |
Molecular Formula | C34H60O13 |
Molecular Weight | 676.81 |
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Description | Benzyl-PEG11-Boc is a polyethylene glycol (PEG)-based PROTAC linker that can be used in the synthesis of a series of PROTACs. |
Synonyms | Benzyl-PEG11-t-butyl ester; tert-butyl 1-phenyl-2,5,8,11,14,17,20,23,26,29,32-undecaoxapentatriacontan-35-oate |
IUPAC Name | tert-butyl 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate |
Canonical SMILES | O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCC1=CC=CC=C1 |
InChI | InChI=1S/C34H60O13/c1-34(2,3)47-33(35)9-10-36-11-12-37-13-14-38-15-16-39-17-18-40-19-20-41-21-22-42-23-24-43-25-26-44-27-28-45-29-30-46-31-32-7-5-4-6-8-32/h4-8H,9-31H2,1-3H3 |
InChIKey | XYOWUTMHQVRGNO-UHFFFAOYSA-N |
Purity | ≥95% |
Storage | Store at 2-8°C |
Benzyl-PEG11-Boc, a polyethylene glycol (PEG)-based linker widely utilized in bioconjugation, plays a pivotal role in facilitating the attachment of biomolecules to synthetic molecules or surfaces. Here are four key applications of Benzyl-PEG11-Boc, presented with high perplexity and burstiness: Drug Delivery Systems: Leveraging the versatile capabilities of Benzyl-PEG11-Boc, scientists significantly enhance the solubility and stability of drug molecules, thus enabling their secure and efficient delivery to targeted tissues. By intricately bonding drugs to PEG chains, the pharmacokinetic properties are notably improved, leading to extended circulation time and reduced immunogenicity. This groundbreaking method is particularly advantageous for the development of precise and controlled-release drug delivery systems, elevating the precision and efficacy of therapeutic interventions to unprecedented levels. Protein and Peptide Conjugation: Widely embraced in the arena of protein and peptide conjugation, Benzyl-PEG11-Boc plays a crucial role in attaching these vital biomolecules to a myriad of surfaces, nanoparticles, or other biomolecules. PEGylation of proteins proves instrumental in mitigating aggregation, bolstering stability, and augmenting bioavailability. This innovative technique stands as a cornerstone in advancing therapeutic proteins, vaccines, and diagnostic agents, propelling the biomedicine frontier into a realm of enhanced versatility and efficacy. Surface Modification: Spearheading advancements in surface modification for medical devices, biosensors, and implants, Benzyl-PEG11-Boc imparts these crucial instruments with anti-fouling and biocompatible characteristics. Coating surfaces with PEG serves to minimize the adsorption of proteins and cells, thereby reducing the likelihood of immune responses while elevating device performance standards. This indispensable application within the biomedical domain ensures the durability and efficacy of implanted devices, revolutionizing patient care and treatment outcomes with transformative impact. Biomolecular Research: Within the intricate realm of biomolecular research, Benzyl-PEG11-Boc emerges as a pivotal linker in constructing intricate multifunctional molecules, enabling profound exploration of protein-protein interactions, enzyme kinetics, and cell signaling pathways with unparalleled precision. The adaptability and reliability of Benzyl-PEG11-Boc in forming stable and functional bioconjugates position it as an indispensable tool in molecular biology and biochemistry studies. |
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Resources
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Technical Information
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- How to Perform Polyethylene Glycol (PEG) Modification?
- Hydrophobic Interaction Chromatography (HIC) Technique
- Introduction of Polyethylene Glycol (PEG)
- Ion Exchange Chromatography (IEX) Technique
- PEG for Chemical Synthesis
- PEG for Cosmetic Application
- PEG for Drug Delivery
- PEG for Imaging Diagnosis
- PEG for Pharmaceutical Preparation
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- PEG Purification Techniques of Plasmid DNA
- PEGylated Protein Purification Techniques
- Polyethylene Glycol (PEG) Modifier Selection Guide
- Radiolabeling Technique
- SDS-PAGE Technique
- Size Exclusion Chromatography (SEC) Technique
- Ultrafiltration Technique
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Industry News
- Applications of PEG-DSPE: Drug Carriers and Drug Delivery
- Applications of Polyethylene Glycol (PEG) as Medical Devices
- Cholesterol: Definition, Structure, Synthesis, Types and Functions
- Classification of Lipid-Based Vaccine Adjuvants
- FDA approved PEGylated Products
- FDA-Approved Antibody-Drug Conjugates up to 2024
- How are Liposomes Different from Micelles?
- How Lipid Nanoparticles (LNPs) Deliver RNA Drugs?
- Hyaluronic Acid & PEGylated Hyaluronic Acid
- Ionizable Lipids for RNA Delivery
- Lipid Classification and Drug Delivery Systems
- Lipid Formulations: Key Absorption-Enhancing Technologies in New Drug Development
- Lipid-Drug Conjugates (LDCs) for Nanoparticle Drug Delivery
- Liposome in Drug Delivery
- Overview of Liposome Preparation Process
- PEG in Pharmaceutical Preparations (I): Solvents, Lubricants, Adhesives and More
- PEG in Pharmaceutical Preparations (II): Stabilizers, Plasticizers and Modification Materials
- PEG Linkers in Antibody Drug Conjugates and PROTACs
- PEG-DSPE Block Copolymers and Their Derivatives
- PEGylated Drugs: Definition, Structure, Classification and Benefits
- PEGylated RGD Peptides: A Promising Tool for Targeted Drug Delivery
- Pharmacokinetics and Bioanalysis of PEGylated Drugs
- Polyethylene Glycol (PEG) Modified Targeting Nanomaterials
- Preparation Method of PEG Hydrogel
- The PROTAC Technology in Drug Development
- Vaccines: Definition, History, Ingredients, Types and Mechanism of Action
- What are Lipid Excipients and Their Applications?
- What are Lipid Nanoparticles and Their Applications?
- What are Lipid-Drug Conjugates (LDCs)?
- What are Lipids?
- What are Monodispersed and Polydispersed PEGs?
- What are PEG Lipids?
- What are Phospholipids?
- What are Sterols? - Definition, Structure, Function, Examples and Uses
- What is Biotinylation and Biotinylated PEG?
- What is Click Chemistry?
- What is Hydrogel?
- What is Methoxy Polyethylene Glycol (mPEG)?
- What is Nanogels and Its Applications?
- What is the Formulation of Lipid Nanoparticles (LNPs)?
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BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.
PEGylation of Peptides
and Proteins
Reduce the Immunogenicity of Peptide/Protein Drugs
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APPLICATIONS
PEG linkers For Drug
Improved Circulation Half-Life
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