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Benzyl-PEG11-Boc

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Category Benzyl-PEGn-Boc
Catalog NO. BPG-0108
Product Name Benzyl-PEG11-Boc
Molecular Formula C34H60O13
Molecular Weight 676.81
Benzyl-PEG11-Boc
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Product Information

Description Benzyl-PEG11-Boc is a polyethylene glycol (PEG)-based PROTAC linker that can be used in the synthesis of a series of PROTACs.
Synonyms Benzyl-PEG11-t-butyl ester; tert-butyl 1-phenyl-2,5,8,11,14,17,20,23,26,29,32-undecaoxapentatriacontan-35-oate
IUPAC Name tert-butyl 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCC1=CC=CC=C1
InChI InChI=1S/C34H60O13/c1-34(2,3)47-33(35)9-10-36-11-12-37-13-14-38-15-16-39-17-18-40-19-20-41-21-22-42-23-24-43-25-26-44-27-28-45-29-30-46-31-32-7-5-4-6-8-32/h4-8H,9-31H2,1-3H3
InChIKey XYOWUTMHQVRGNO-UHFFFAOYSA-N
Purity ≥95%
Storage Store at 2-8°C

Benzyl-PEG11-Boc, a polyethylene glycol (PEG)-based linker widely utilized in bioconjugation, plays a pivotal role in facilitating the attachment of biomolecules to synthetic molecules or surfaces. Here are four key applications of Benzyl-PEG11-Boc, presented with high perplexity and burstiness:

Drug Delivery Systems: Leveraging the versatile capabilities of Benzyl-PEG11-Boc, scientists significantly enhance the solubility and stability of drug molecules, thus enabling their secure and efficient delivery to targeted tissues. By intricately bonding drugs to PEG chains, the pharmacokinetic properties are notably improved, leading to extended circulation time and reduced immunogenicity. This groundbreaking method is particularly advantageous for the development of precise and controlled-release drug delivery systems, elevating the precision and efficacy of therapeutic interventions to unprecedented levels.

Protein and Peptide Conjugation: Widely embraced in the arena of protein and peptide conjugation, Benzyl-PEG11-Boc plays a crucial role in attaching these vital biomolecules to a myriad of surfaces, nanoparticles, or other biomolecules. PEGylation of proteins proves instrumental in mitigating aggregation, bolstering stability, and augmenting bioavailability. This innovative technique stands as a cornerstone in advancing therapeutic proteins, vaccines, and diagnostic agents, propelling the biomedicine frontier into a realm of enhanced versatility and efficacy.

Surface Modification: Spearheading advancements in surface modification for medical devices, biosensors, and implants, Benzyl-PEG11-Boc imparts these crucial instruments with anti-fouling and biocompatible characteristics. Coating surfaces with PEG serves to minimize the adsorption of proteins and cells, thereby reducing the likelihood of immune responses while elevating device performance standards. This indispensable application within the biomedical domain ensures the durability and efficacy of implanted devices, revolutionizing patient care and treatment outcomes with transformative impact.

Biomolecular Research: Within the intricate realm of biomolecular research, Benzyl-PEG11-Boc emerges as a pivotal linker in constructing intricate multifunctional molecules, enabling profound exploration of protein-protein interactions, enzyme kinetics, and cell signaling pathways with unparalleled precision. The adaptability and reliability of Benzyl-PEG11-Boc in forming stable and functional bioconjugates position it as an indispensable tool in molecular biology and biochemistry studies.

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PEGylation of Peptides and Proteins

PEGylation of Peptides
and Proteins

Reduce the Immunogenicity of Peptide/Protein Drugs

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APPLICATIONS

APPLICATIONS

PEG linkers For Drug

Improved Circulation Half-Life

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