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Azido-PEG9-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane

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Category	Azido-PEGn-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane
Catalog NO.	BPG-0893
Product Name	Azido-PEG9-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane
Molecular Formula	C46H86N4O19
Molecular Weight	999.18

Azido-PEG9-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane

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Description	Azido-PEG9-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a branched PEG derivative with a terminal azide group and three t-butyl esters. The azide group enables PEGylation via Click Chemistry. The t-butyl protected carboxyl groups can be deprotected under mild acidic conditions.
Synonyms	tert-butyl 1-azido-32,32-bis((3-(tert-butoxy)-3-oxopropoxy)methyl)-30-oxo-3,6,9,12,15,18,21,24,27,34-decaoxa-31-azaheptatriacontan-37-oate
IUPAC Name	tert-butyl 3-[2-[3-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-3-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]-2-[[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]methyl]propoxy]propanoate
Canonical SMILES	O=C(OC(C)(C)C)CCOCC(COCCC(OC(C)(C)C)=O)(NC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O)COCCC(OC(C)(C)C)=O
InChI	InChI=1S/C46H86N4O19/c1-43(2,3)67-40(52)11-16-64-36-46(37-65-17-12-41(53)68-44(4,5)6,38-66-18-13-42(54)69-45(7,8)9)49-39(51)10-15-55-20-22-57-24-26-59-28-30-61-32-34-63-35-33-62-31-29-60-27-25-58-23-21-56-19-14-48-50-47/h10-38H2,1-9H3,(H,49,51)
InChIKey	BIXBEWXALQXYKS-UHFFFAOYSA-N
Purity	≥95%
Storage	Store at 2-8°C

Azido-PEG9-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane, a versatile chemical reagent utilized in biomedical and biochemical research, holds myriad applications. Here are four key applications intricately described with a high degree of perplexity and burstiness:

Bioconjugation: Serving as a cornerstone of bioconjugation processes, this compound facilitates the coupling of biomolecules such as proteins, peptides, and nucleic acids to diverse surfaces or other molecules. The presence of the azide group allows for seamless "click" chemistry reactions with alkyne-functionalized molecules, playing a pivotal role in constructing intricate biomolecular assemblies and executing targeted drug delivery strategies.

Drug Delivery Systems: Spearheading advancements in drug delivery systems, Azido-PEG9-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane incorporates a polyethylene glycol (PEG) segment to improve the solubility and biocompatibility of therapeutic agents. By modifying drug molecules with this reagent, researchers can enhance drug stability, lengthen circulation time, and achieve precise target-specific delivery.

Surface Modification: Extending its utility beyond bioconjugation, this compound plays a vital role in surface functionalization, particularly in the realm of biosensors and medical devices. Surface functionalization with PEG derivatives reduces nonspecific binding, thereby augmenting biosensor sensitivity and specificity. This pivotal application is crucial for developing highly efficient diagnostic tools and enhancing the biocompatibility of medical implants.

Proteomics Research: Emerging as a valuable asset in proteomics research, Azido-PEG9-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane enables the labeling and analysis of proteins within complex biological samples. The selective labeling capability of the azide group empowers the study of protein interactions, modifications, and functions, providing crucial insights into protein networks and dynamics. This application deepens our comprehension of proteomics, aiding in the identification of potential disease biomarkers, and propelling the field of proteomics research forward.

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