Azido-PEG3-acetic acid

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Category	Azido-PEGn-CH2COOH
Catalog NO.	BPG-1800
Product Name	Azido-PEG3-acetic acid
CAS	172531-37-2
Molecular Formula	C8H15N3O5
Molecular Weight	233.22

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Description	N3-PEG3-CH2COOH is a PROTAC linker, which refers to the alkyl/ether composition. N3-PEG3-CH2COOH can be used in the synthesis of a series of PROTACs. N3-PEG3-CH2COOH is a PEG derivative containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.
Synonyms	Azido-PEG3-CH2CO2H;11-Azido-3,6,9-trioxaundecanoic Acid; N3-PEG3-CH2COOH; {2-[2-(2-Azidoethoxy)ethoxy]ethoxy}acetic acid; Acetic acid, 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-; Azido-PEG3-CH2COOH
IUPAC Name	2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]acetic acid
Canonical SMILES	C(COCCOCCOCC(=O)O)N=[N+]=[N-]
InChI	InChI=1S/C8H15N3O5/c9-11-10-1-2-14-3-4-15-5-6-16-7-8(12)13/h1-7H2,(H,12,13)
InChIKey	GIXBCECBLAEYKA-UHFFFAOYSA-N
Purity	>95%
Solubility	Soluble in DCM, DMF, DMSO, Water
Appearance	Light Yellow to Brown Clear Liquid
Storage	Store at 2-8°C
Exact Mass	233.10117059

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