Azido-PEG2-hydrazide-Boc

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Category	Azido-PEGn-hydrazide-Boc
Catalog NO.	BPG-0012
Product Name	Azido-PEG2-hydrazide-Boc
CAS	2100306-56-5
Molecular Formula	C12H23N5O5
Molecular Weight	317.35

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Description	Azido-PEG2-hydrazide-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Synonyms	Azido-PEG2-t-Boc-hydrazide;Azido-PEG2-t-Boc-Hydrazide; tert-butyl 2-(3-(2-(2-azidoethoxy)ethoxy)propanoyl)hydrazine-1-carboxylate; Hydrazinecarboxylic acid, 2-[3-[2-(2-azidoethoxy)ethoxy]-1-oxopropyl]-, 1,1-dimethylethyl ester; 2-Methyl-2-propanyl 2-{3-[2-(2-azidoethoxy)ethoxy]propanoyl}hydrazinecarboxylate; Propanoic acid, 3-[2-(2-azidoethoxy)ethoxy]-, 2-[(1,1-dimethylethoxy)carbonyl]hydrazide
IUPAC Name	tert-butyl N-[3-[2-(2-azidoethoxy)ethoxy]propanoylamino]carbamate
Canonical SMILES	CC(C)(C)OC(=O)NNC(=O)CCOCCOCCN=[N+]=[N-]
InChI	InChI=1S/C12H23N5O5/c1-12(2,3)22-11(19)16-15-10(18)4-6-20-8-9-21-7-5-14-17-13/h4-9H2,1-3H3,(H,15,18)(H,16,19)
InChIKey	JYNHRXFEKXQQDG-UHFFFAOYSA-N
Purity	≥95%
Appearance	Light Yellow Oily Matter
Storage	Store at 2-8°C

Azido-PEG2-hydrazide-Boc, a versatile and functionalized linker widely applied in biochemical research and drug development, exhibits diverse applications. Here are four key applications articulated with a high degree of perplexity and burstiness:

Conjugation Chemistry: Renowned for its role in bioconjugation reactions, Azido-PEG2-hydrazide-Boc facilitates the linkage of biomolecules like proteins and peptides through azide-alkyne cycloaddition, a hallmark of click chemistry. This process engenders stable connections between disparate molecular entities, offering a valuable method for crafting bioconjugates tailored for targeted drug delivery and imaging endeavors.

Drug Delivery Systems: Within the realm of drug delivery, Azido-PEG2-hydrazide-Boc finds utility in anchoring active pharmaceutical ingredients to carrier molecules. Leveraging PEGylation for enhanced pharmacokinetics and drug stability, researchers exploit this linker to fashion more potent and less immunogenic therapeutic agents, representing a significant stride in pharmaceutical innovation.

Bioorthogonal Chemistry: A cornerstone of bioorthogonal chemistry, Azido-PEG2-hydrazide-Boc enables precise modifications of biomolecules devoid of disruption to native biological processes. Its application in labeling proteins, nucleic acids, and other biomolecules within live cells furnishes a potent tool for investigating dynamic cellular phenomena and intricate molecular interactions, shedding light on the intricacies of cellular dynamics.

Surface Modification: Beyond its conventional uses, Azido-PEG2-hydrazide-Boc also serves as a pivotal agent in the modification of nanoparticles and diverse materials to augment biocompatibility and functionality. By facilitating the grafting of the azide group onto alkyne-functionalized surfaces, it engenders a robust and adaptable coating. These modified surfaces find application in biosensor development, diagnostics, and therapeutic interventions, underscoring the versatility and significance of this compound in advanced material science.

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