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Azido-PEG12-hydrazide-Boc

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Category Azido-PEGn-hydrazide-Boc
Catalog NO. BPG-0014
Product Name Azido-PEG12-hydrazide-Boc
Molecular Formula C32H63N5O15
Molecular Weight 757.88
Azido-PEG12-hydrazide-Boc
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Product Information

Description Azido-PEG12-hydrazide-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Synonyms Azido-PEG12-t-Boc-Hydrazide; tert-butyl 42-azido-4-oxo-7,10,13,16,19,22,25,28,31,34,37,40-dodecaoxa-2,3-diazadotetracontanoate
IUPAC Name tert-butyl N-[3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]carbamate
Canonical SMILES O=C(OC(C)(C)C)NNC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O
InChI InChI=1S/C32H63N5O15/c1-32(2,3)52-31(39)36-35-30(38)4-6-40-8-10-42-12-14-44-16-18-46-20-22-48-24-26-50-28-29-51-27-25-49-23-21-47-19-17-45-15-13-43-11-9-41-7-5-34-37-33/h4-29H2,1-3H3,(H,35,38)(H,36,39)
InChIKey YYSCDAKZBRRCKI-UHFFFAOYSA-N
Purity ≥95%
Storage Store at 2-8°C

Azido-PEG12-hydrazide-Boc, a versatile chemical reagent, finds its place in diverse bioconjugation and cross-linking endeavors. Here are four key applications of this compound, presented with a high degree of perplexity and burstiness:

Protein-Protein Cross-Linking: Delving into the realm of protein interactions, Azido-PEG12-hydrazide-Boc emerges as a pivotal player in protein cross-linking endeavors. By binding to specific protein sites, it orchestrates the creation of stable protein-protein conjugates, shedding light on protein functions and dynamics within intricate biological landscapes.

Drug Delivery Systems: At the forefront of drug delivery innovation, Azido-PEG12-hydrazide-Boc takes center stage in crafting targeted and efficient drug delivery systems. Its prowess in forming steadfast conjugates with drugs and targeting ligands enables precise delivery to desired cellular destinations, amplifying therapeutic efficacy while minimizing off-target repercussions.

Surface Modification: Unveiling its utility in surface modification terrain, this reagent proves indispensable for enhancing nanoparticles, biosensors, and medical devices. By furnishing functional groups for subsequent conjugation, it facilitates the attachment of bioactive molecules like antibodies, peptides, or nucleic acids to surfaces, ushering in a new era of biofunctional surfaces poised to elevate performance benchmarks in diagnostics and therapeutic realms.

Chemical Biology Research: In the intricate domain of chemical biology, Azido-PEG12-hydrazide-Boc takes on a pivotal role in introducing azide groups into biomolecules for click chemistry reactions. This strategic maneuver fuels investigations into biomolecular interactions, pathways, and functions, serving as an essential ally in labeling, tracking, and manipulating biomolecules amidst the complexities of biological milieus.

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PEGylation of Peptides and Proteins

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