Aminooxy-PEG9-acid
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Category | Aminooxy-PEGn-acid |
Catalog NO. | BPG-0736 |
Product Name | Aminooxy-PEG9-acid |
Molecular Formula | C21H43NO12 |
Molecular Weight | 501.57 |
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Description | Aminooxy-PEG9-acid is a PEG derivative containing an aminooxy group and a terminal carboxylic acid. The aminooxy group can be used in bioconjugation. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. |
Synonyms | Aminoxy-PEG9-acid; 1-(aminooxy)-3,6,9,12,15,18,21,24,27-nonaoxatriacontan-30-oic acid |
IUPAC Name | 3-[2-[2-[2-[2-[2-[2-[2-[2-(2-aminooxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid |
Canonical SMILES | O=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCON |
InChI | InChI=1S/C21H43NO12/c22-34-20-19-33-18-17-32-16-15-31-14-13-30-12-11-29-10-9-28-8-7-27-6-5-26-4-3-25-2-1-21(23)24/h1-20,22H2,(H,23,24) |
InChIKey | VGBAIOUOJZSGAC-UHFFFAOYSA-N |
Purity | ≥95% |
Related CAS | 2588488-52-0 (polymer) |
Appearance | Pale Yellow or Colorless Oily Matter |
Storage | Store at 2-8°C |
Aminooxy-PEG9-acid, a versatile compound with diverse applications in chemical biology and bioconjugation, is renowned for its utility. Here we explore four key applications of Aminooxy-PEG9-acid, presented with a high degree of perplexity and burstiness. Protein Labeling: Through precise interactions with carbonyl groups on proteins, Aminooxy-PEG9-acid finds its niche in protein labeling techniques. This selective reaction enables the attachment of various labels—ranging from fluorophores to biotin—to proteins, facilitating detection and tracking. This methodology plays a pivotal role in unraveling the intricate dynamics and interactions of proteins within cellular and in vitro milieus. Drug Delivery Systems: Aminooxy-PEG9-acid assumes a pivotal role in the realm of drug conjugates by serving as a critical linker between pharmaceutical compounds and targeting moieties. This linkage enhances drug solubility and stability while ensuring targeted delivery, particularly to sites like tumor cells. Such innovative drug delivery systems not only amplify therapeutic efficacy but also minimize unwanted side effects, optimizing patient outcomes. Biosensor Development: In the domain of biosensors, Aminooxy-PEG9-acid emerges as a key reagent for enhancing sensing elements and surfaces, thereby boosting sensitivity and specificity. By conjugating sensing elements to PEGylated surfaces, biosensors achieve heightened capabilities in detecting biomarkers with speed and precision. This application is indispensable in medical diagnostics and environmental surveillance, offering rapid and accurate detection methodologies. Glycoprotein Modification: Aminooxy-PEG9-acid showcases its versatility in the precise modification of glycoproteins, shedding light on their functional roles and structural intricacies. Through targeted reactions with oxidized glycan moieties, this compound enables the attachment of diverse probes and tags. Such nuanced modifications empower researchers to uncover the significance of glycoproteins in biological pathways and disease progression, providing invaluable insights into complex biological phenomena. |
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Technical Information
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