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Aminooxy-PEG7-alcohol

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Category Aminooxy-PEGn-alcohol
Catalog NO. BPG-0758
Product Name Aminooxy-PEG7-alcohol
Molecular Formula C14H31NO8
Molecular Weight 341.40
Aminooxy-PEG7-alcohol
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Description Aminooxy-PEG7-alcohol is a non-cleavable 7-unit PEG ADC linker that is used in the synthesis of antibody conjugated drugs (ADCs). Aminooxy-PEG7-alcohol is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules.
Synonyms 20-(aminooxy)-3,6,9,12,15,18-hexaoxaicosan-1-ol
IUPAC Name 2-[2-[2-[2-[2-[2-(2-aminooxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Canonical SMILES C(COCCOCCOCCOCCOCCOCCON)O
InChI InChI=1S/C14H31NO8/c15-23-14-13-22-12-11-21-10-9-20-8-7-19-6-5-18-4-3-17-2-1-16/h16H,1-15H2
InChIKey WYWUBJZMXIFFBD-UHFFFAOYSA-N
Purity ≥95%
Appearance Pale Yellow or Colorless Oily Matter
Storage Store at 2-8°C

Aminooxy-PEG7-alcohol, a versatile compound widely utilized in biochemical research and various applications, demonstrates a diverse array of uses. Here are four key applications presented with high perplexity and burstiness:

Bioconjugation: Playing a pivotal role in bioconjugation methodologies, Aminooxy-PEG7-alcohol is extensively employed in linking biomolecules, such as proteins and peptides, through oxime ligation. This method provides a stable and efficient approach to connecting diverse molecules, facilitating the creation of bioconjugates used for diagnostic and therapeutic purposes. The integration of the PEG linker not only enhances solubility but also alleviates steric hindrance, ultimately boosting the efficacy of the conjugation process.

Drug Delivery Systems: In the realm of drug delivery, Aminooxy-PEG7-alcohol serves as a critical functional linker for constructing sophisticated drug conjugates and delivery vehicles. By binding to drug molecules or targeting ligands, it ensures precise delivery to specific tissues or cells. The process of PEGylation extends circulation time and decreases immunogenicity, ultimately enhancing the therapeutic effectiveness of the drug and optimizing treatment outcomes.

Surface Modification: Playing a crucial role in surface modification applications involving nanomaterials, biomaterials, and medical devices, Aminooxy-PEG7-alcohol aims to enhance biocompatibility and functionality. This compound facilitates the development of hydrophilic surfaces resistant to proteins, reducing nonspecific binding and improving overall performance. Such modifications are essential for the advancement of biosensors, implants, and other medical devices, elevating standards in healthcare technology.

Chemical Biology Research: Within the field of chemical biology, Aminooxy-PEG7-alcohol emerges as a key component in labeling and tracking biomolecules within complex biological systems. By attaching fluorescent dyes and other tags, researchers gain the ability to visualize and analyze biomolecular interactions in real-time, offering valuable insights into cellular processes and molecular dynamics.

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PEGylation of Peptides and Proteins

PEGylation of Peptides
and Proteins

Reduce the Immunogenicity of Peptide/Protein Drugs

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APPLICATIONS

APPLICATIONS

PEG linkers For Drug

Improved Circulation Half-Life

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