Amino-PEG6-alcohol
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| Category | Amino-PEGn-alcohol |
| Catalog NO. | BPG-1886 |
| Product Name | Amino-PEG6-alcohol |
| CAS | 39160-70-8 |
| Molecular Formula | C12H27NO6 |
| Molecular Weight | 281.35 |
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| Description | Amino-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
| Synonyms | 17-Amino-3,6,9,12,15-pentaoxaheptadecan-1-ol; H2N-PEG6-OH; 1-Aminohexaethylene Glycol |
| IUPAC Name | 2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol |
| Canonical SMILES | C(COCCOCCOCCOCCOCCO)N |
| InChI | InChI=1S/C12H27NO6/c13-1-3-15-5-7-17-9-11-19-12-10-18-8-6-16-4-2-14/h14H,1-13H2 |
| InChIKey | ICUIZKMGHRMMDZ-UHFFFAOYSA-N |
| Boiling Point | 388.0±37.0 °C at 760 mmHg |
| Flash Point | 188.5±26.5 °C |
| Purity | ≥95% |
| Density | 1.1±0.1 g/cm3 |
| Solubility | Soluble in DMSO (10 mm) |
| Related CAS | 933789-97-0 (polymer) |
| Appearance | Pale Yellow or Colorless Oily Matter |
| Storage | Store at 2-8°C |
| Exact Mass | 281.18383758 |
| Vapor Pressure | 0.0±2.0 mmHg at 25°C |
| LogP | -2.80 |
| Pictogram(s) | Irritant |
| Signal | Warning |
| Precautionary Statement Codes | P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 |
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Amino-PEG6-alcohol, a polyethylene glycol derivative, has numerous applications in the fields of biotechnology and pharmaceuticals. Here are some key applications of Amino-PEG6-alcohol: Drug Delivery Systems: Amino-PEG6-alcohol is often used to improve the solubility and stability of pharmaceutical compounds. By conjugating drugs with PEG, the circulation time in the bloodstream is increased, enhancing the bioavailability and therapeutic efficacy. This can lead to more effective treatments with reduced dosing frequency. Protein Modification: In biotechnology, Amino-PEG6-alcohol is used to modify proteins and peptides to improve their pharmacokinetic properties. The PEGylation process can reduce immunogenicity and increase the half-life of therapeutic proteins. This modification is crucial for the development of biologics and peptide-based drugs. Diagnostics: Amino-PEG6-alcohol finds application in the development of diagnostic assays and imaging agents. By attaching PEG chains to antibodies or other biomolecules, the stability and functionality of diagnostic reagents can be enhanced. This results in more accurate and reliable diagnostic tests and imaging techniques. Bioconjugation: Amino-PEG6-alcohol is extensively used in bioconjugation techniques for attaching various biomolecules, such as enzymes, antibodies, and nucleic acids. The PEG linker provides flexibility and reduces steric hindrance, facilitating the formation of stable conjugates. This is essential for creating multifunctional bioconjugates for research and therapeutic applications. |
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Resources
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Technical Information
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- How to Perform Polyethylene Glycol (PEG) Modification?
- Hydrophobic Interaction Chromatography (HIC) Technique
- Introduction of Polyethylene Glycol (PEG)
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- Polyethylene Glycol (PEG) Modifier Selection Guide
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Industry News
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- FDA-Approved Antibody-Drug Conjugates up to 2024
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- Lipid Formulations: Key Absorption-Enhancing Technologies in New Drug Development
- Lipid-Drug Conjugates (LDCs) for Nanoparticle Drug Delivery
- Liposome in Drug Delivery
- Overview of Liposome Preparation Process
- PEG in Pharmaceutical Preparations (I): Solvents, Lubricants, Adhesives and More
- PEG in Pharmaceutical Preparations (II): Stabilizers, Plasticizers and Modification Materials
- PEG Linkers in Antibody Drug Conjugates and PROTACs
- PEG-DSPE Block Copolymers and Their Derivatives
- PEGylated Drugs: Definition, Structure, Classification and Benefits
- PEGylated RGD Peptides: A Promising Tool for Targeted Drug Delivery
- Pharmacokinetics and Bioanalysis of PEGylated Drugs
- Polyethylene Glycol (PEG) Modified Targeting Nanomaterials
- Preparation Method of PEG Hydrogel
- The PROTAC Technology in Drug Development
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PEGylation of Peptides
and Proteins
Reduce the Immunogenicity of Peptide/Protein Drugs
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APPLICATIONS
PEG linkers For Drug
Improved Circulation Half-Life
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