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Allyl-CONH-PEG6-COOH

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Category Allyl-CONH-PEGn-COOH
Catalog NO. BPG-0094
Product Name Allyl-CONH-PEG6-COOH
Molecular Formula C18H33NO9
Molecular Weight 407.46
Allyl-CONH-PEG6-COOH
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Product Information

Description Allyl-CONH-PEG6-COOH is a polyethylene glycol (PEG)-based PROTAC linker that can be used in the synthesis of a series of PROTACs.
Synonyms 3-oxo-7,10,13,16,19,22-hexaoxa-4-azapentacos-1-en-25-oic acid
IUPAC Name 3-[2-[2-[2-[2-[2-[2-(prop-2-enoylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES O=C(O)CCOCCOCCOCCOCCOCCOCCNC(C=C)=O
InChI InChI=1S/C18H33NO9/c1-2-17(20)19-4-6-24-8-10-26-12-14-28-16-15-27-13-11-25-9-7-23-5-3-18(21)22/h2H,1,3-16H2,(H,19,20)(H,21,22)
InChIKey OFSQAKGUXFQILF-UHFFFAOYSA-N
Purity ≥95%
Storage Store at 2-8°C

Allyl-CONH-PEG6-COOH is an innovative compound in the field of molecular and materials science, providing various applications. Here are some key applications of Allyl-CONH-PEG6-COOH:

Drug Delivery Systems: Allyl-CONH-PEG6-COOH is used in the design of advanced drug delivery systems due to its biocompatible and hydrophilic properties. This compound facilitates the attachment of therapeutic agents to polyethylene glycol (PEG), which enhances drug solubility and stability. It also enables targeted drug delivery, ensuring that medications reach specific tissues or cells.

Surface Modification: This compound can be employed to modify the surfaces of medical devices and implants. By coating these surfaces with Allyl-CONH-PEG6-COOH, researchers can prevent protein adsorption and cell adhesion, reducing the risk of infection and improving biocompatibility. This surface modification can lead to more successful implantations and longer-lasting medical devices.

Bioconjugation Strategies: Allyl-CONH-PEG6-COOH is valuable in bioconjugation techniques, which involve linking biomolecules to other entities such as nanoparticles, enzymes, or therapeutic agents. The presence of PEG6 enhances solubility and reduces immunogenicity of the conjugated molecules. These bioconjugates can be used in diagnostic assays, therapeutic applications, and in the design of novel biomaterials.

Hydrogels for Tissue Engineering: Allyl-CONH-PEG6-COOH can be incorporated into hydrogel formulations used in tissue engineering. The compound's reactive groups allow for cross-linking, thereby creating hydrogels with tunable mechanical and chemical properties. These hydrogels can support cell growth and differentiation, making them suitable scaffolds for regenerating tissues and organs.

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PEGylation of Peptides and Proteins

PEGylation of Peptides
and Proteins

Reduce the Immunogenicity of Peptide/Protein Drugs

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