Acs-PEG8-propargyl

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Category	AcS-PEGn-propargyl
Catalog NO.	BPG-1110
Product Name	Acs-PEG8-propargyl
CAS	1422540-90-6
Molecular Formula	C21H38O9S
Molecular Weight	466.57

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Description	Acs-PEG8-propargyl is a PEG linker containing a sulfur acetyl group and a propargyl moiety. The sulfur acetyl group can be deprotected to produce a thiol compound. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The hydrophilic PEG linker increases the water solubility of the compounds in the aqueous media.
Synonyms	S-acetyl-PEG8-Propargyl; Acetylthio-PEG8-Alkyne; S-acetyl-PEG8-alkyne; S-(3,6,9,12,15,18,21,24-octaoxaheptacos-26-yn-1-yl) ethanethioate
IUPAC Name	S-[2-[2-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl] ethanethioate
Canonical SMILES	CC(=O)SCCOCCOCCOCCOCCOCCOCCOCCOCC#C
InChI	InChI=1S/C21H38O9S/c1-3-4-23-5-6-24-7-8-25-9-10-26-11-12-27-13-14-28-15-16-29-17-18-30-19-20-31-21(2)22/h1H,4-20H2,2H3
InChIKey	MATNNORDXGRTCZ-UHFFFAOYSA-N
Purity	≥95%
Storage	Store at 2-8°C

Acs-PEG8-propargyl, a versatile PEGylation reagent, finds extensive utility in modifying biomolecules across diverse applications in bioscience and biotechnology. Here are four key applications of Acs-PEG8-propargyl presented with a high degree of perplexity and burstiness:

Bioorthogonal Chemistry: Positioned at the core of bioorthogonal chemistry reactions, Acs-PEG8-propargyl assumes a pivotal role in attaching polyethylene glycol (PEG) chains to biomolecules. This intricate process enhances the solubility and stability of proteins, peptides, and other macromolecules while concurrently diminishing their immunogenicity. Such intricate modifications are essential for crafting biopharmaceuticals with augmented pharmacokinetics and mitigated side effects, heralding a novel epoch in advanced medical therapeutics.

Drug Delivery Systems: Acs-PEG8-propargyl emerges as a foundational element in fabricating PEGylated drug delivery systems, wherein therapeutic agents amalgamate with PEG chains to enhance delivery efficiency and enable controlled release. PEGylation elongates the circulation time of drugs in the bloodstream, diminishes renal clearance, and boosts drug solubility. These advantages heighten the efficacy of PEGylated drugs in targeting specific tissues and curtailing off-target effects, thereby revolutionizing the landscape of targeted drug delivery.

Surface Modification: Exploiting the capabilities of Acs-PEG8-propargyl, scientists can tailor the surfaces of nanoparticles, biosensors, and medical devices. By affixing PEG chains to surface structures, researchers avert protein adsorption and cell adhesion, culminating in heightened biocompatibility and reduced nonspecific interactions. This breakthrough holds immense potential for applications in diagnostics, imaging, and implantable devices, where enhanced surface modification can markedly enhance device performance and patient outcomes.

Site-Specific Conjugation: Acs-PEG8-propargyl empowers researchers to achieve site-specific conjugation of biomolecules, a pivotal facet in preserving their biological activity and functionality. By selectively targeting specific amino acid residues or functional groups, scientists can execute precise and efficient PEGylation, ensuring the creation of uniform and reproducible bioconjugates for therapeutic, diagnostic, and analytical applications. This technique symbolizes a significant milestone in advanced biomolecule modification, paving the way for enhanced precision and efficacy in bioconjugate design.

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