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7-Keto Cholesterol-[d7]

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Category Bile Acid Standards
Catalog NO. BPG-3125
Product Name 7-Keto Cholesterol-[d7]
CAS 127684-08-6
Molecular Formula C27H37D7O2
Molecular Weight 407.68
7-Keto Cholesterol-[d7]
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Product Information

Description 7-Ketocholesterol-[25,26,26,26,27,27,27-d7] is a labelled analog of 7-Ketocholesterol, which is a metabolite of Cholesterol.
Synonyms 7-Ketocholesterol (25,26,26,26,27,27,27-D7); 7-Ketocholesterol-d7; 7-oxo-cholest-5-en-3beta-ol(d7)
IUPAC Name (3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-17-[(2R)-6,7,7,7-tetradeuterio-6-(trideuteriomethyl)heptan-2-yl]-1,2,3,4,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-7-one
Canonical SMILES CC(C)CCCC(C)C1CCC2C1(CCC3C2C(=O)C=C4C3(CCC(C4)O)C)C
InChI InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-23,25,28H,6-15H2,1-5H3/t18-,20+,21-,22+,23+,25+,26+,27-/m1/s1/i1D3,2D3,17D
InChIKey YIKKMWSQVKJCOP-KVZGVLACSA-N
Boiling Point 516.685ºC at 760 mmHg
Melting Point 166-168°C
Purity 98% by CP; 99% atom D
Density 1.05 g/cm3
Solubility Soluble in Chloroform, Methanol
Appearance White to Off-white Solid
Application A labelled metabolite of Cholesterol.
Shelf Life 1 Year
Storage Store at -20°C
Exact Mass 407.378
Hygroscopic No
Light Sensitive No
Percent Composition C 79.54%, H 12.61%, O 7.85%
References 1. Ménégaut L, Thomas C, Jalil A, Julla JB, Magnani C, Ceroi A, Basmaciyan L, Dumont A, Le Goff W, Mathew MJ, Rébé C, Dérangère V, Laubriet A, Crespy V, Pais de Barros JP, Steinmetz E, Venteclef N, Saas P, Lagrost L, Masson D. Interplay between Liver X Receptor and Hypoxia Inducible Factor 1α Potentiates Interleukin-1β Production in Human Macrophages. Cell Rep. 2020 May 19;31(7):107665. doi: 10.1016/j.celrep.2020.107665. PMID: 32433974. PubMed ID: 32433974.
2. Anosov AA, Smirnova EY, Sharakshane AA, Nikolayeva EA, Zhdankina YS. Increase in the current variance in bilayer lipid membranes near phase transition as a result of the occurrence of hydrophobic defects. Biochim Biophys Acta Biomembr. 2020 Feb 1;1862(2):183147. doi: 10.1016/j.bbamem.2019.183147. Epub 2019 Dec 6. PMID: 31812627. PubMed ID: 31874216.
3. Rossin D, Dias IHK, Solej M, Milic I, Pitt AR, Iaia N, Scoppapietra L, Devitt A, Nano M, Degiuli M, Volante M, Caccia C, Leoni V, Griffiths HR, Spickett CM, Poli G, Biasi F. Increased production of 27-hydroxycholesterol in human colorectal cancer advanced stage: Possible contribution to cancer cell survival and infiltration. Free Radic Biol Med. 2019 Mar 23;136:35-44. doi: 10.1016/j.freeradbiomed.2019.03.020. [Epub ahead of print]...PubMed ID: 30910555.

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