14:0 PE-DTPA (Gd) Diammonium salt

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Category	Lipids For Bicelle Formation
Catalog NO.	BPG-3100
Product Name	14:0 PE-DTPA (Gd) Diammonium salt
CAS	2260795-83-1
Molecular Formula	C47H90GdN6O17P
Molecular Weight	1199.47

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Product Information

Description	Lipid nanoparticles containing DMPE-DTPA(Gd) provide high quality contrast enhanced vascular MRI at 97% reduced dose of Gd and do not rely on renal clearance.
Synonyms	1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt)(diammonium salt); 1,2-ditetradecanoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt)(diammonium salt); DMPE-DTPA (Gd)(diammonium salt)
Purity	>99%
Related CAS	1149339-24-1 (free acid)
Appearance	White Solid
Shelf Life	1 Year
Storage	Store at -20°C
Exact Mass	1199.534
Hygroscopic	No
Light Sensitive	No
Percent Composition	C 47.06%, H 7.56%, Gd 13.11%, N 7.01%, O 22.68%, P 2.58%

References

1. Barazza A, Blachford C, Even-Or O, Joaquin VA, Briley-Saebo KC, Chen W, Jiang XC, Mulder WJ, Cormode DP, Fayad ZA, Fisher EA. The complex fate in plasma of gadolinium incorporated into high-density lipoproteins used for magnetic imaging of atherosclerotic plaques. Bioconjug Chem. 2013 Jun 19;24(6):1039-48. doi: 10.1021/bc400105j. Epub 2013 May 10. PMID: 23617731; PMCID: PMC3928357. PubMed ID: 23617731.
2. Bui T, Stevenson J, Hoekman J, Zhang S, Maravilla K, Ho RJ. Novel Gd nanoparticles enhance vascular contrast for high-resolution magnetic resonance imaging. PLoS One. 2010 Sep 30;5(9):e13082. doi: 10.1371/journal.pone.0013082. PMID: 20927340; PMCID: PMC2948015. PubMed ID: 20927340.
3. Briley-Saebo KC, Geninatti-Crich S, Cormode DP, Barazza A, Mulder WJ, Chen W, Giovenzana GB, Fisher EA, Aime S, Fayad ZA. High-relaxivity gadolinium-modified high-density lipoproteins as magnetic resonance imaging contrast agents. J Phys Chem B. 2009 May 7;113(18):6283-9. doi: 10.1021/jp8108286. PMID: 19361222; PMCID: PMC2688742. PubMed ID: 19361222.
4. Bertini I, Bianchini F, Calorini L, Colagrande S, Fragai M, Franchi A, Gallo O, Gavazzi C, Luchinat C. Persistent contrast enhancement by sterically stabilized paramagnetic liposomes in murine melanoma. Magn Reson Med. 2004 Sep;52(3):669-72. doi: 10.1002/mrm.20189. PMID: 15334589. PubMed ID: 15334589.

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