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1,1,1-Trifluoroethyl-PEG10-azide

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Category	1,1,1-Trifluoroethyl-PEGn-azide
Catalog NO.	BPG-0933
Product Name	1,1,1-Trifluoroethyl-PEG10-azide
Molecular Formula	C22H42F3N3O10
Molecular Weight	565.56

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Description	1,1,1-Trifluoroethyl-PEG10-azide is a crosslinker containing an azide group and a trifluroethyl group. The azide group can participate in Click Chemistry reactions with reagents such as alkynes, DBCO and BCN. The hydrophilic PEG spacer increases solubility in aqueous media. The trifluoroethyl group is used to react with lysine and other primary amine groups in proteins, antibodies, and other molecules and surfaces.
Synonyms	32-azido-1,1,1-trifluoro-3,6,9,12,15,18,21,24,27,30-decaoxadotriacontane
IUPAC Name	2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-1,1,1-trifluoroethane
Canonical SMILES	FC(F)(F)COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
InChI	InChI=1S/C22H42F3N3O10/c23-22(24,25)21-38-20-19-37-18-17-36-16-15-35-14-13-34-12-11-33-10-9-32-8-7-31-6-5-30-4-3-29-2-1-27-28-26/h1-21H2
InChIKey	DEENNGRNTGFWHE-UHFFFAOYSA-N
Purity	≥95%
Storage	Store at 2-8°C

111-Trifluoroethyl-PEG10-azide, a versatile compound with diverse applications in biosciences, plays a pivotal role in various fields. Here are four key applications presented with high perplexity and burstiness:

Bioconjugation: 111-Trifluoroethyl-PEG10-azide serves as a cornerstone in bioconjugation strategies, enabling the stable attachment of biomolecules to an array of surfaces or carriers. Its azide group exhibits remarkable reactivity in click chemistry reactions, particularly with alkynes, facilitating the intricate formation of complex molecular assemblies. This capability is essential for the creation of cutting-edge biosensors, sophisticated drug delivery systems, and innovative diagnostic tools.

Protein Labeling: This compound emerges as a key player in site-specific protein labeling, empowering precise functional examinations of proteins within biological systems. Through the strategic linkage of the azide group to proteins, researchers can introduce fluorescent tags or other probes using click chemistry. This methodology proves invaluable for tracking protein localization, deciphering intricate protein-protein interactions, and visually depicting cellular processes in unprecedented detail.

Drug Delivery: In the realm of drug delivery, 111-Trifluoroethyl-PEG10-azide plays a vital role in enhancing the solubility and stability of therapeutic agents within delivery platforms. The incorporation of the polyethylene glycol (PEG) component enhances biocompatibility and prolongs circulation time in the bloodstream, making it an optimal candidate for nanoparticle-based drug delivery systems designed to target specific tissues or cells with precision and efficacy.

Material Science: Within the realm of material science, 111-Trifluoroethyl-PEG10-azide assumes a transformative role in surface modification and the creation of functionalized polymers. Its ability to partake in orthogonal chemical reactions unlocks the potential for designing advanced materials boasting unique properties. These modified materials find applications across diverse fields, including the development of innovative hydrogels, high-performance coatings, and cutting-edge biomedical devices that push the boundaries of material science and engineering.

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