-20°C for long-term preservation, keep in dry and avoid sunlight. Avoid repeated freezing and thawing.
Soluble in water, DMSO and DMF. Freshly prepared before use.
Polyglutamic acid (PGA) is a new class of biodegradable polymers. It is non-toxic to organisms and non-immunogenic. It has no side effects and has good biocompatibility. Highly hydrophobic PGA coupled with water-soluble PEG forms excellent carriers for drug delivery. The various reactive terminal groups on the PEG can crosslink with different molecules. PEG-PGA derivatives are good drug crosslinkers as well as drug delivery vehicles.
1. Akagi T, Higashi M, Kaneko T, et al. Hydrolytic and enzymatic degradation of nanoparticles based on amphiphilic poly (γ-glutamic acid)-graft-L-phenylalanine copolymers. Biomacromolecules, 2006, 7(1): 297-303. 2. Akagi T, Kaneko T, Kida T, et al. Multifunctional conjugation of proteins on/into bio-nanoparticles prepared by amphiphilic poly (γ-glutamic acid).Journal of Biomaterials Science, Polymer Edition, 2006, 17(8): 875-892.