PEGylated Biodegradable Polymers Synthesis

BOC Sciences provides synthesis services of PEGylated biodegradable polymers according to the specific needs of our customers. We also provide various high quality diblock (A-B) and triblock (A-B-A) copolymers of PEG with dendrimer, polycaprolactone (PCL), polylactic acid (LA), polylactide-co-glycolide (PLGA), polylysine (Plys), hyaluronic acid (HA), RGD peptides and polyglutamic acid (PGA).

Biodegradable Polymers

Biodegradable polymers are a special class of polymer, which largely consisted of ester, amide and ether functional groups. These polymers can break down after its intended purpose to result in natural byproducts. Their structure determines their properties and breakdown mechanism. Due to their stability and durability, biodegradable polymers have important applications in various fields, such as biology, medicine, packaging and agriculture. Biodegradable polymers have broad development prospects in the future.

PEGylated Biodegradable Polymers

In the field of biomedicine, new materials consisting of biodegradable macromolecules linked with polyethylene glycol (PEG) have extended characteristics and have applications in microparticles, nanoparticles, micelles, hydrogel formulations and drug delivery. PEG copolymer is an ideal polymeric backbone material. PEGylated block copolymer can be used as a scaffold material and can be combined with tissue living cells as an implantable material, which can be used for surgical sutures, cell membrane construction, artificial blood vessels, artificial ligaments or tendons. Moreover, PEGylated biodegradable copolymers can be used in degradable medical devices that do not require human intervention for removal from the body.

The core-shell structure formed by the PEGylated biodegradable copolymer has advantages used as a drug carrier because of its long circulation, good stability, high drug loading capacity, improved bioavailability, and reduced toxic side effects. The PEG chain attached to the polymer surface can mask the positive charge to reduce the toxicity of the polymer. The PEGylated biodegradable material can be used as a drug delivery carrier to prolong the sustained release of the drug, thereby enabling fewer administration times and avoiding interval administration. Diblock copolymers formed from PEG and other macromolecules generally have good biocompatibility and safety, they can reduce the irritating effects of some drugs on the gastrointestinal tract, and avoid the toxic side effects certain drugs to the whole body, especially the liver and kidneys. In addition, the diblock copolymers formed by PEG is also amphiphilic. They are capable of self-assembly in an aqueous solution to encapsulate the drug to improve the solubility of the drug, and also the coated drugs have better stability. The targeted drug delivery system is also a hot research direction. By adjusting the molecular weight of PEG and other block biodegradable macromolecules, the release time and place of the drugs can be tuned, thereby achieving targeted drug delivery.

Figure 1. Schematic formation and structure of PLA–PEG shell cross-linked micelles and PLA–PEG–PLA core cross-linked micelles.Figure 1. Schematic formation and structure of PLA–PEG shell cross-linked micelles and PLA–PEG–PLA core cross-linked micelles. (Li, J., et al., 2015)

BOC Sciences provides high quality PEGylated biodegradable copolymer products and professional customized synthesis services. If you have any specific needs, please contact us immediately.

References

  1. Rösler A, et al., 2012. Advanced drug delivery devices via self-assembly of amphiphilic block copolymers. Advanced drug delivery reviews, 64, pp. 270–279.
  2. Cheng J, et al., 2007. Formulation of functionalized PLGA–PEG nanoparticles for in vivo targeted drug delivery. Biomaterials, 28 (5), pp. 869–876.
  3. Li, J., et al., 2015. Poly(lactic acid)/poly(ethylene glycol) block copolymer based shell or core cross-linked micelles for controlled release of hydrophobic drug. RSC Advances, 5 (25), pp. 19484–19492.

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