-20°C for long-term preservation, keep in dry and avoid sunlight. Avoid repeated freezing and thawing.
Soluble in water, DMSO and DMF. Freshly prepared before use.
Arg-Gly-Asp (RGD) polypeptide is a common tumor active targeting polypeptide that can directly act on tumor targets to form an active targeting effect. The applications of RGD peptides includes inhibition of apoptosis, angiogenesis and tumor formation. RGD peptides are used as coating surfaces for biomaterials to enhance drug delivery and imaging for disease diagnosis. PEGylated RGD can be cross-linked with other molecules via reactive terminal groups on PEG for use in various biomedical studies.
1. Chen X, Park R, Shahinian A H, et al. Pharmacokinetics and tumor retention of 125I-labeled RGD peptide are improved by PEGylation.Nuclear medicine and biology, 2004, 31(1): 11-19. 2. Kong L, Alves C S, Hou W, et al. RGD peptide-modified dendrimer-entrapped gold nanoparticles enable highly efficient and specific gene delivery to stem cells.ACS applied materials & interfaces, 2015, 7(8): 4833-4843.