-20°C for long-term preservation, keep in dry and avoid sunlight. Avoid repeated freezing and thawing.
Soluble in water, DMSO and DMF. Freshly prepared before use.
The compound coupled with polyethylene glycol and polylactic acid-glycolic acid copolymer is a degradable functional high molecular organic compound. PLGA-PEG derivatives with good biocompatibility, non-toxic, good capsular and film forming properties are widely used in pharmaceutical, medical engineering materials and modern industrial fields. PLGA-PEG derivatives can be used as drug-loaded microspheres, vesicles, microcapsules and micelles for sustained release and controlled release of drugs.
1. Avgoustakis K, Beletsi A, Panagi Z, et al. Effect of copolymer composition on the physicochemical characteristics, in vitro stability, and biodistribution of PLGA-mPEG nanoparticles. International journal of pharmaceutics, 2003, 259(1-2): 115-127. 2. Liu P, Yu H, Sun Y, et al. A mPEG-PLGA-b-PLL copolymer carrier for adriamycin and siRNA delivery. Biomaterials, 2012, 33(17): 4403-4412.