-20°C for long-term preservation, keep in dry and avoid sunlight. Avoid repeated freezing and thawing.
Soluble in water, DMSO and DMF. Freshly prepared before use.
Polyethylene glycol and polylactic acid coupled compounds are widely used in the field of biomedicine. Drugs modified by the PEG-PLA series of derivatives have better water solubility, encapsulation efficiency and drug loading. Polylactic acid (PLA) is a new type of biomaterial that is a renewable biodegradable material. PLA can be used to prepare novel targeting products such as micelles or vesicles. PLA-PEG derivatives can be applied to targeted drug delivery systems.
1. Portnoff, Alyse D., et al. An antidote approach to reduce risk and broaden utility of antibody-based therapeutics. Journal of Biological Chemistry, 2017, 292(20): 8498-8506. 2. Simon, Manuel, Uwe Zangemeister-Wittke, and Andreas Plückthun. Facile double-functionalization of designed ankyrin repeat proteins using click and thiol chemistries. Bioconjugate chemistry, 2012, 23(2): 279-286.