-20°C for long-term preservation, keep in dry and avoid sunlight. Avoid repeated freezing and thawing.
Soluble in water and most organic solvents, freshly prepared before use.
mPEG-ALD (methoxy-polyethylene glycol-propionaldehyde) is a linear, monofunctional modified PEG terminated with a methoxy group at one end and an aldehyde group at the other end. The aldehyde group can react with the N-terminus of the peptide and protein to form a C=N double bond, which can be further used for this reaction. The mPEG-ALD or ketone derivative can also undergo a reversible reaction with hydrazine to form a hydrazide bond.
1. Zhai, Yanqin, et al. Enhanced circulation half-life of site-specific PEGylated rhG-CSF: optimization of PEG molecular weight. Journal of biotechnology, 2009, 142(3-4): 259-266. 2. Kim, Tae Hyung, et al. PEGylated TNF-related apoptosis-inducing ligand (TRAIL) analogues: pharmacokinetics and antitumor effects. Bioconjugate chemistry, 2011, 22(8): 1631-1637.