-20°C for long-term preservation, keep in dry and avoid sunlight. Avoid repeated freezing and thawing.
Soluble in regular aqueous solution as well as most organic solvents.
mPEG-AA can be used to modify polypeptides, proteins and other materials with reactive groups. The carboxyl group can easily form a stable amide bond with an amino group, and can also form an ester bond with a hydroxyl group. Polyethylene glycol can increase solubility and stability. It also inhibits the non-specific binding of the charged molecule to the modified surface by reducing the immunogenicity of the polypeptide and protein.
1. Abuchowski, Abraham, et al. Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase. Journal of Biological Chemistry, 1977, 252(11): 3582-3586. 2. Savoca, Kenneth V., et al. Preparation of a non-immunogenic arginase by the covalent attachment of polyethylene glycol. Biochimica et Biophysica Acta (BBA)-Protein Structure, 1979, 578(1): 47-53.