MAL-PEG-NH2, MW 3.4k

  • Catalog No.
  • BPG-0889
  • Product Name
  • MAL-PEG-NH2, MW 3.4k
  • Storage
  • -20°C for long-term preservation, keep in dry and avoid sunlight. Avoid repeated freezing and thawing.
  • Solubility
  • Soluble in water, DMSO and DMF. Freshly prepared before use.
  • Description
  • MAL-PEG-NH2 is Maleimide PEG that can modify the thiol group. A stable oxime ether bond is formed with the thiol group at a pH of 6.5–7.5. Under copper catalysis, azide can undergo a click chemical reaction with an alkyne group in an aqueous solution to form a nitrogen-containing five-membered heterocyclic ring. Heterobifunctional PEG can be attached to different molecules or materials to extend the richness of different molecular combinations.
  • References
  • 1. Baklaushev V P, Nukolova N N, Khalansky A S, et al. Treatment of glioma by cisplatin-loaded nanogels conjugated with monoclonal antibodies against Cx43 and BSAT1.Drug delivery, 2015, 22(3): 276-285.
    2. Kuang X, Zhou S, Guo W, et al. SS-31 peptide enables mitochondrial targeting drug delivery: a promising therapeutic alteration to prevent hair cell damage from aminoglycosides.Drug delivery, 2017, 24(1): 1750-1761.

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