-20°C for long-term preservation, keep in dry and avoid sunlight. Avoid repeated freezing and thawing.
Soluble in water, DMSO and DMF. Freshly prepared before use.
GAS-PEG-GAS has a longer hydrolysis half-life. This Homobifunctionalized PEG derivatives have wide applications in peptides, proteins, lipids, other small molecules and surface modifications. Drug PEGylation can alter its dispersity and solubility in aqueous solutions. PEG modification can create a spatial barrier around the drug, reduce the enzymatic hydrolysis of the drug, avoid the rapid elimination of kidney metabolism, and allow the drug to be recognized by cells of the immune system.
1. Harrison, Emma, et al. A comparison of gold nanoparticle surface co-functionalization approaches using polyethylene glycol (PEG) and the effect on stability, non-specific protein adsorption and internalization. Materials Science and Engineering: C, 2016, 62: 710-718. 2. Li, Fanyi, et al. Cartilage tissue formation through assembly of microgels containing mesenchymal stem cells. Acta biomaterialia, 2018, 77: 48-62.