-20°C for long-term preservation, keep in dry and avoid sunlight. Avoid repeated freezing and thawing.
Soluble in water, DMSO and DMF. Freshly prepared before use.
GA-PEG-GA has two identical activated carboxyl terminal groups, which can also be condensed with a hydroxyl group to give an ester bond. This homobifunctionalized PEG derivative has wide applications in peptides, proteins, lipids, other small molecules and surface modifications. Drug PEGylation can alter its dispersity and solubility in aqueous solutions. PEG modification can create a spatial barrier around the drug, reduce the enzymatic hydrolysis of the drug, avoid the rapid elimination of kidney metabolism, and allow the drug to be recognized by cells of the immune system.
1. Ebashi, Iwao, Tetsuo Takigawa, and Masayasu Inoue. Long chain carboxylic acid imide ester. U. S. Patent No. 5,336,782. 9 Aug. 1994. 2. Mougin, Nathalie, Aude Livoreil, and Jean Mondet. Cosmetic composition forming after application a supramolecular polymer. U. S. Patent No. 7,862,805. 4 Jan. 2011. 3. Agnew, Brian, et al. Labeling and detection of nucleic acids. U. S. Patent No. 8,114,636. 14 Feb. 2012.