The two ends of the molecular chain of cRGD-PEG-NH2 are cyclic peptide cRGD and amine group, respectively. It is a linear heterobifunctional PEG reagent. Applications of RGD peptides include inhibition of apoptosis, angiogenesis and tumorigenesis. RGD peptides are used as coating surfaces for biomaterials to enhance drug delivery and imaging for disease diagnosis. PEGated RGDs can be cross-linked with other molecules through reactive end groups on PEGs and used in a variety of biomedical research. Amines may react with carboxylic acids or activated NHS esters. cRGD-PEG-NH2 is an effective target material, which can be used as an anti-tumor drug carrier and effective targeted delivery.
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