4-Arm PEG-Thiol

Synonyms: Four-Arm PEG-Thiol; Four-Arm polyethylene glycol-Thiol

Four-Arm polyethylene glycol-Thiol (4-Arm PEG-Thiol) is a multiarm PEG derivative with thiol groups at each terminal of the four arms connected to one pentaerythritol core. It is a viscous liquid or white solid and needs to be kept away from light at -20℃. Four arm polyethylene glycol derivatives have a variety of active groups that can be used to modify proteins, peptides and other materials through their functional groups. The reactive free thiol, SH, sulfhydryl, or mercapto groups selectively react with maleimide and transition metal surface including gold, silver, etc. PEG-SH can be easily air oxidized to form S-S disulfide (disulphide) bonds, which can be reversed with reducing agents. It is a useful reagent for reversible PEGylation and PEG hydrogel.