Synonyms: HZ-PEG-HZ; Hydrazide-polyethylene glycol-Hydrazide; HZ-polyethylene glycol-HZ
Hydrazide-PEG-Hydrazide is a PEG derivative whose molecular chain segments are functionalized by hydrazide. Hydrazide-PEG-Hydrazide can be used for reversible peglization by reacting with ketones or aldehydes to form acyl bonds, but this bond is sensitive to pH. In addition, it can be used to activate carboxylic acids, such as succinimide NHS esters. HydrazZide-PEG-Hydrazide can modify proteins by carboxylic or other amine-reactive chemical groups, and can also react quickly with carbohydrate residues. It also inhibits the nonspecific binding of charged molecules to the modified surface.
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