Bis-PEG5-acetic acid

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Category	Small-molecule Homobifunctional PEG
Catalog NO.	BPG-2011
Product Name	Bis-PEG5-acetic acid
CAS	77855-76-6
Molecular Formula	C14H26O10
Molecular Weight	354.35

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Description	PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. PEG6-(CH2CO2H)2 is a PEG derivative containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.
Synonyms	COOH-CH2-PEG6-CH2-COOH; COOH-CH2-PEG5-CH2-COOH; 3,6,9,12,15,18-Hexaoxaeicosanedioic acid; 3,6,9,12,15,18-Hexaoxaicosane-1,20-dioic acid
IUPAC Name	2-[2-[2-[2-[2-[2-(carboxymethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
Canonical SMILES	C(COCCOCCOCC(=O)O)OCCOCCOCC(=O)O
InChI	InChI=1S/C14H26O10/c15-13(16)11-23-9-7-21-5-3-19-1-2-20-4-6-22-8-10-24-12-14(17)18/h1-12H2,(H,15,16)(H,17,18)
InChIKey	DCQRSABUSOYSIY-UHFFFAOYSA-N
Boiling Point	524.8±45.0 °C at 760 mmHg
Purity	≥95%
Density	1.234±0.06 g/cm3 (Predicted)
Solubility	Soluble in DMSO, Water
Appearance	Colorless Oily Liquid
Storage	Store at 2-8°C

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