-20°C for long-term preservation, keep in dry and avoid sunlight. Avoid repeated freezing and thawing.
Soluble in water, DMSO and DMF. Freshly prepared before use.
Alkene-PEG-Alkene has two identical activated terminal groups. Homobifunctionalized PEG derivatives have wide applications in peptides, proteins, lipids, other small molecules and surface modifications. Drug PEGylation can alter its dispersity and solubility in aqueous solutions. PEG modification can create a spatial barrier around the drug, reduce the enzymatic hydrolysis of the drug, avoid the rapid elimination of kidney metabolism, and allow the drug to be recognized by cells of the immune system.
1. Schenk, Franziska C., et al. Dual-functionalized nanostructured biointerfaces by click chemistry. Langmuir, 2014, 30(23): 6897-6905. 2. Maurice, Vincent, et al. Polymer-grafted silicon nanoparticles obtained either via peptide bonding or click chemistry. Macromolecular Chemistry and Physics, 2012, 213(23): 2498-2503.